Systemic Dilation Diathesis in Patients with Abdominal Aortic Aneurysms: A Role for Matrix Metalloproteinase-9?
نویسندگان
چکیده
منابع مشابه
Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms.
Abdominal aortic aneurysms represent a life-threatening condition characterized by chronic inflammation, destructive remodeling of the extracellular matrix, and increased local expression of matrix metalloproteinases (MMPs). Both 92-kD gelatinase (MMP-9) and macrophage elastase (MMP-12) have been implicated in this disease, but it is not known if either is necessary in aneurysmal degeneration. ...
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Elastolytic matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of abdominal aortic aneurysms (AAA), a disorder characterized by chronic aortic wall inflammation and destruction of medial elastin. The purpose of this study was to determine if human macrophage elastase (HME; MMP-12) might participate in this disease. By reverse transcription-polymerase chain reaction, HME m...
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ژورنال
عنوان ژورنال: European Journal of Vascular and Endovascular Surgery
سال: 2005
ISSN: 1078-5884
DOI: 10.1016/j.ejvs.2005.01.009